Tag Archives: sorafenib

Sorafenib is regarded as to have an quickly manageable associated toxicity without a treatment-related mortality.

In patients with hepatocellular carcinoma characterized by vascular invasion and/or extrahepatic illness, Sorafenib is considered  therapy of option. Even though mild liver test abnormalities had been reported in much less than 1% in the patients inside the two huge randomized, … Continue reading

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Sorafenib is actually a small molecule B-RAF inhibitor.

Background and Objectives Activated tyrosine kinases are implicated inside the pathogenesis of chronic and acute leukemia, and represent attractive targets for therapy. Sorafenib (BAY43-9006, Nexavar?) is actually a small molecule B-RAF inhibitor that’s applied for the treatment of renal cell … Continue reading

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Effects of sorafenib on lymphocytic leukemia cells(CLLs)

Fecteau JF, Bharati IS, O’hayre M, Handel TM, Kipps TJ, Messmer D. “Mol Med. 2011 Oct” We have beforehand demonstrated that sorafenib, a multi-kinase inhibitor, exhibits cytotoxic results on CLL cells. Considering that the cellular microenvironment can defend CLL cells … Continue reading

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