Tag Archives: rapamycin

Rapamycin, an inhibitor in the mTOR pathway

Inhibition in the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, which includes yeast, nematodes and fruit flies1-5. However, whether inhibition of mTOR signalling can extend life in a mammalian species was unknown. We report here … Continue reading

Posted in Uncategorized | Tagged | Leave a comment

Rapamycin inhibits osteoclast formation in large cell tumor of bone by way of Middle for Molecular Medication

Rapamycin inhibits osteoclast formation in large cell tumor of bone by way of Middle for Molecular Medication, Robert-Roessle-Str.ten, 13125, Berlin, Germany. Abstract Big cell tumor (GCT) of bone is really a benign sort of tumor, however the existence of hyperactive … Continue reading

Posted in Uncategorized | Tagged | Leave a comment

Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by attenuating mTOR signaling and a 4E-BP1-dependent mechanism

Guntur KV, Guilherme A, Xue “The Journal of Biological Chemistry 2010″ The receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is deemed a grasp regulator of adipocyte differentiation and encourages glucose and lipid metabolic process in mature adipocytes. We lately determined the … Continue reading

Posted in Uncategorized | Tagged | Leave a comment

mTOR Ser-2481 autophosphorylation straight monitors intrinsic mTORC-specific catalytic exercise

Soliman GA, Acosta Jaquez HA, Dunlop E “The Journal of Biological Chemistry 2010″ The mammalian focus on of rapamycin (mTOR) Ser/Thr kinase indicators in at the very least two multiprotein complexes distinguished by their distinct companions and sensitivities to rapamycin. … Continue reading

Posted in Uncategorized | Tagged | Leave a comment

Rapamycin inhibition endothelial cell migration by means of regulation with the cyclin-dependent kinase inhibitor

Moss SC, Lightell DJ Jr, Marx SO, Marks AR, Woods TC “The Journal of Biological Chemistry 2010″ Rapamycin can be a macrolide antibiotic that inhibits vascular smooth muscle mass cell proliferation and migration and that’s utilised clinically on drug-eluting stents … Continue reading

Posted in Uncategorized | Tagged | Leave a comment

Molecular interplay between mammalian target of rapamycin (mTOR) and amyloid-beta

Caccamo A, Majumder S, Richardson A, Robust R, Oddo S “The Journal of Biological Chemistry 2010″ Accumulation of amyloid-beta (Abeta) and Tau is an invariant feature of Alzheimer disease (Ad). The upstream part of Abeta accumulation within the illness pathogenesis … Continue reading

Posted in Uncategorized | Tagged | Leave a comment

what’s the part of Ribosomal protein S6 kinase for rapamycin target for long-term facilitation in Aplysia?

Weatherill DB, Dyer J, Sossin WS “The Journal of Biological Chemistry 2010″ Long-term facilitation (LTF) in Aplysia is actually a leading mobile design for elucidating the biochemical mechanisms of synaptic plasticity underlying learning. In Aplysia, LTF needs translational manage downstream … Continue reading

Posted in Uncategorized | Tagged | Leave a comment

Targeting HER2 signaling pathway for radiosensitization Alternative strategy for therapeutic resistance

Mina No, Eun Jung Choi, In Ah Kim ” Cancer biology & therapy 2010″ Several researchers have indicated risks of bydureon importance of targeting HER-2 signalingto reinforce the anti-tumor activity of ionizing radiation. However, therapeutic resistancepresented by several factors, including … Continue reading

Posted in Uncategorized | Tagged , | Leave a comment