Tag Archives: kinase inhibitor

KRAS or BRAF will underpin acquired resistance to MEK1/2 inhibitors in colorectal cancer cells

Little AS, Balmanno K, Sale MJ, Newman S, Dry JR, Hampson M, Edwards PA, Smith PD, Cook SJ. “Sci Signal. 2011″ Background: The acquisition of resistance to protein kinase inhibitors is actually a expanding dilemma in cancer remedy. We modeled … Continue reading

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Effects of sorafenib on lymphocytic leukemia cells(CLLs)

Fecteau JF, Bharati IS, O’hayre M, Handel TM, Kipps TJ, Messmer D. “Mol Med. 2011 Oct” We have beforehand demonstrated that sorafenib, a multi-kinase inhibitor, exhibits cytotoxic results on CLL cells. Considering that the cellular microenvironment can defend CLL cells … Continue reading

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